Endocrine Abstracts

IntroductionThe aim of this study, which was conducted for the first time in Ukraine, was to analyze a glycemic control in patients with different types of diabetes mellitus (DM), including neonatal (ND) and maturity onset diabetes of the young (MODY) and changing their treatment after the results of genetic testing.Materials and methodsThe Ukrainian Pediatric Diabetes Register was established in 2002 and inc...

Background: According to the statistics of the Ministry of Health of Ukraine, before the accident at the Chernobyl nuclear power plant, the incidence of thyroid cancer in children under 14 years of age was on average 0.04 per 100,000 children, however long-term consequences of the accident have not been analyzed.Material and methods: We studied the incidence of thyroid cancer during the last 35 years in Ukraine in children under the age of 14 and 18 y.o....

Introduction: Usually GHD women require higher GH doses than males, especially those with exogenous oestrogens (guidelines). This fact was assessed in real-life practice in France.Methods: Data were from a Registry in 84 sites treating AGHD (Norditropin®) up to 5 years. Naïve patients did not receive GH 6 months before inclusion. Statistics were descriptive.Results: 328 patients (129 naïve) were included; mean age 49...

Objective: IGF1 is the most useful serum marker for GH dose titration in adults. The authors focused on the GH dose adjustment with extreme IGF1 values (<−2S.D.; >+2S.D.).Methods: French observational study of AGHD patients treated with Norditropin®.Prospective follow up until 5 years.Results (median [Q1; Q3]):: 328 AGHD, 39.2±14.3 years old wer...

Introduction: We report the clinical presentation of pheochromocytoma with Cushing’s syndrome due to ectopic production of ACTH, and assess the histopathological diagnosis, treatment modality and prognostic factors compared with the literature.Results: Cushing’s Syndrome due to ectopic ACTH production is uncommon and due to pheochromocytoma is extremely rare. We discuss the case of a 50-year-old female who initially presented with vague, non-sp...

Transsphenoidal surgery is the most efficient primary treatment for acromegaly. However, some patients do not meet remission criteria after operation. Mixed growth hormone (GH)/prolactin (PRL)-secreting pituitary adenomas are known to predict poor surgical outcome. The aim of our study was to evaluate immunohistochemical markers in pure GH-and mixed GH/PRL-containing tumors and to investigate their prognostic value. In our study we included 39 acromegalic patients, who underwe...

Introduction: Interaction between genetic and environmental factors is the foundation of the pathogenesis of autoimmune thyroiditis (AIT). One of the important factors is iodine supply. Iodine deficiency is the main cause of goiter, dysfunction of the thyroid gland, disorders of mental and physical development. Main solution of that problem is the iodine salt consumption. It can decrease iodine deficiency, but the RF doesn’t have general programs of salt iodization and ha...

The aim: To determine the prognostic parameters affecting the course of acromegaly (A.) and the effectiveness of drug therapy (MT).Matherials and methods: 779 patients of A. [218 men (28%)] aged 60 (48/69) years, [Me(25%/75%)] were included in the Moscow register. The prevalence of A. in Moscow is 61.6; the incidence is 4.0 cases/million inhabitants. The treatment algorithm included surgical aid (495 patients), primary (I) or secondary (II) MT (584) and ...

Background: SARS-CoV-2 profoundly impacts population health through both acute infection and post-COVID period. Multiple studies make it clear that metabolic diseases can significantly affect the course of COVID-19.Aim: To study the course of post-COVID period in patients with type 2 diabetes mellitus (DM2).Methods: The international registry ACTIV SARS-CoV-2 (NCT04492384) was established to study COVID-19 in the Eurasian region. T...

Background: The literature shows that body mass index (BMI) and blood glucose levels can significantly influence the course of infectious diseases. In the light of ongoing SARS-CoV-2 pandemic, its rational treatment and prevention are strategic public health goals.Aim: To study the relationship between BMI and serum glucose levels during the acute period of COVID-19 in hospitalized patients.«ACTIV SARS-CoV-2» registry was established to evaluat...